Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vivo experiment with the electrocatalytic glucose sensor in sheep

W Preidel1, I von Lucadou, W Lager

  • 1Siemens AG, Erlangen, Germany.

Biosensors & Bioelectronics
|January 1, 1993
PubMed
Summary

A novel electrocatalytic glucose sensor for diabetes management demonstrated stable performance for over 71 days in sheep. This implantable sensor offers reliable, long-term blood glucose monitoring with minimal recalibration needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo temperature measurement during transcatheter endomyocardial Nd-YAG laser irradiation in dogs.

Lasers in medical science·2010
Same author

Long-term responses of canine lungs to acidic particles.

Inhalation toxicology·2009
Same author

Performance evaluation of IVC systems.

Laboratory animals·2005
Same author

Image guided interstitial laser thermotherapy: a canine model evaluated by magnetic resonance imaging and quantitative autoradiography.

Acta neurochirurgica·2004
Same author

Health effects of sulfur-related environmental air pollution. II. Cellular and molecular parameters of injury.

Inhalation toxicology·1999
Same author

Health effects of sulfur-related environmental air pollution. III. Nonspecific respiratory defense capacities.

Inhalation toxicology·1999

Area of Science:

  • Biomedical Engineering
  • Electrocatalysis
  • Diabetes Technology

Background:

  • Diabetes therapy requires precise insulin dosage control.
  • Long-term, reliable glucose monitoring is crucial for effective diabetes management.
  • Existing glucose monitoring methods have limitations in long-term stability and calibration.

Purpose of the Study:

  • To develop and evaluate an electrocatalytic glucose sensor for long-term implantation in diabetes therapy.
  • To assess the sensor's performance, stability, and reliability in a chronic in-vivo model.
  • To determine the feasibility of continuous glucose monitoring for extended periods.

Main Methods:

  • Development of an implantable electrocatalytic glucose sensor.
  • In-vivo implantation of the sensor as a flow-through cell in a sheep's carotid artery.

Related Experiment Videos

  • Continuous monitoring of blood glucose levels over 71 days with a portable electronic unit.

    • Main Results:

    • The sensor demonstrated stable performance and reliable measurements for over 71 days.
    • Stable sensor calibrations were achieved, with one calibration valid for 33 days (2.5 mM mean error).
    • Host reactions and cross-sensitivities to lactate and ethanol had minimal impact on sensor function, with minor calibration adjustments needed.

    Conclusions:

    • The developed electrocatalytic glucose sensor is suitable for long-term implantation and reliable in-vivo glucose monitoring.
    • The sensor exhibits excellent calibration stability, reducing the need for frequent recalibration.
    • Further improvements will focus on enhancing calibration stability and adapting the sensor for clinical applications in diabetes management.