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Related Experiment Videos

Acquired von Willebrand's syndrome associated with decrease of plasminogen activator and its inhibitor during

H Levesque1, J Y Borg, N Cailleux

  • 1Service de Médecine Interne, Centre Hospitalier Universitaire de Rouen-Boisguillaume, France.

The European Journal of Medicine
|May 1, 1993
PubMed
Summary

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Hypothyroidism is frequently associated with von Willebrand

Area of Science:

  • Endocrinology
  • Hematology
  • Molecular Biology

Background:

  • Hypothyroidism can affect hemostasis.
  • Von Willebrand's disease (vWD) is a bleeding disorder.
  • Thyroid hormones influence various physiological processes, including coagulation factors.

Purpose of the Study:

  • To investigate the prevalence of von Willebrand's disease during hypothyroidism.
  • To examine the impact of thyroid hormone replacement therapy on vWD factors, tissue plasminogen activator (tPA), and plasminogen activator inhibitor 1 (PAI).

Main Methods:

  • Prospective study of eleven hypothyroid patients.
  • Monitoring of Factor VIII coagulant activity (VIIIc), von Willebrand factor antigen (vWf:Ag), and von Willebrand factor ristocetin cofactor activity (vWf:RCo).

Related Experiment Videos

  • Assay of tPA antigen and PAI activity before and after hormone supplementation.

    • Main Results:

    • Five patients (45%) exhibited laboratory evidence of type I vWD.
    • Thyroid hormone treatment normalized or increased vWD factors in most patients.
    • Correction of hypothyroidism led to increased tPA and PAI levels.

    Conclusions:

    • Von Willebrand's disease is common in hypothyroid patients.
    • Hypothyroidism may impair von Willebrand factor synthesis.
    • Thyroid hormone therapy positively influences vWD parameters and the fibrinolytic system.