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Fluoxetine, amitriptyline and the electroencephalogram

M Tarn1, J G Edwards, E M Sedgwick

  • 1Department of Clinical Neurophysiology, Wessex Neurological Centre, Southampton General Hospital, UK.

Journal of Affective Disorders
|September 1, 1993
PubMed
Summary

This study found that 4 weeks of fluoxetine or amitriptyline treatment in depressed patients significantly decreased beta activity on electroencephalograms (EEG). No EEG evidence of drowsiness or epileptiform activity was observed.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Depression is a common mood disorder.
  • Electroencephalography (EEG) measures brain activity.
  • Antidepressant medications like fluoxetine and amitriptyline are used to treat depression.

Purpose of the Study:

  • To investigate the effects of fluoxetine and amitriptyline on EEG activity in depressed patients.
  • To assess changes in brain activity after 4 weeks of antidepressant treatment.

Main Methods:

  • Patients with depression received either fluoxetine or amitriptyline for 4 weeks.
  • Electroencephalograms (EEGs) were recorded before and after treatment.
  • EEG data were analyzed visually and using power spectrum analysis, blinded to patient, treatment, and time point.

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Main Results:

  • Visual assessment showed no significant differences in alpha, beta, or theta activity between treatment groups.
  • Power spectrum analysis revealed a significant reduction in beta activity after 4 weeks of treatment.
  • No EEG evidence of drowsiness or epileptiform activity was detected in either treatment group.

Conclusions:

  • Four weeks of treatment with fluoxetine or amitriptyline led to a significant decrease in beta activity in depressed patients.
  • EEG monitoring did not reveal adverse effects like drowsiness or epileptiform activity during treatment.