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Schistosomiasis

D R Lucey1, J H Maguire

  • 1Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Infectious Disease Clinics of North America
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Schistosomiasis is a curable parasitic infection causing tissue damage, especially in the GI and GU tracts. Praziquantel is the recommended treatment for all forms of schistosomiasis in travelers.

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Area of Science:

  • Tropical medicine
  • Parasitology
  • Immunology

Background:

  • Schistosomiasis is a parasitic disease caused by flatworms of the genus Schistosoma.
  • It affects millions globally, primarily in tropical and subtropical regions.
  • The infection can lead to chronic health issues if untreated.

Observation:

  • The parasite eggs trigger a granulomatous immune response, causing tissue pathology.
  • Gastrointestinal and genitourinary tracts are particularly affected.
  • Schistosomiasis is not endemic to the US due to the absence of specific snail hosts.

Findings:

  • Schistosomiasis can persist for up to 30 years in human hosts.
  • The parasite cannot reproduce within the human body.
  • Praziquantel is effective against all schistosome species and clinical presentations.

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Implications:

  • Physicians in North America should be aware of schistosomiasis in travelers and expatriates.
  • Prompt diagnosis and treatment with praziquantel are crucial for managing schistosomiasis.
  • Understanding the host-parasite interaction is key to developing new therapeutic strategies.