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Comparison of anatomically-defined versus physiologically-based regional localization: effects on PET-FDG
S M Resnick1, J S Karp, B Turetsky
1Laboratory of Personality and Cognition, GRC/NIA, Baltimore, Maryland 21224.
Summary
Quantifying brain metabolism using PET 18F-fluorodeoxyglucose (FDG) imaging is robust across MRI-based and PET-based analysis methods when no major structural abnormalities exist. Refined anatomical delineation is needed for improved accuracy with advanced imaging.
Area of Science:
- Neuroimaging
- Medical Physics
- Radiochemistry
Background:
- Anatomical imaging enhances functional brain imaging accuracy through better regional definition.
- Limited data exist on how regional localization impacts metabolic image quantitation without structural pathology.
Purpose of the Study:
- To compare MRI-based and PET-based approaches for analyzing PET 18F-fluorodeoxyglucose (FDG) images.
- To assess the impact of different regional localization methods on metabolic quantitation.
Main Methods:
- Compared MRI-based (individual anatomy adjustment) versus PET-based (global adjustment) template analysis of PET FDG images.
- Determined glucose metabolic rates and volume-to-whole brain ratios in 78 regions across five subjects.
- Assessed interoperator and intraoperator agreement and measurement stability.
Main Results:
- High interoperator agreement was found for both MRI-based and PET-based approaches.
- High intraoperator agreement was observed between MRI-based and PET-based metabolic values.
- Metabolic rates and ratios demonstrated stability across operators and methods, with low coefficients of variation.
Conclusions:
- PET 18F-fluorodeoxyglucose (FDG) image quantitation is relatively robust to analysis approach in the absence of gross structural abnormalities.
- Improved accuracy in high-resolution anatomic and functional imaging necessitates more refined anatomical image delineation.