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Involvement of nitric oxide in noradrenaline-induced increase in blood flow through brown adipose tissue
T Nagashima1, H Ohinata, A Kuroshima
1Department of Physiology I, Asahikawa Medical College, Japan.
Life Sciences
|January 1, 1994
Abstract:
N omega-nitro-L-arginine methyl ester (L-NAME) (80 mg), a NO synthase blocker, completely abolished noradrenaline (NA)-induced increase in blood flow through brown adipose tissue (BAT) in the urethan-anesthetized rat. L-NAME suppressed NA-induced increase in blood flow dose-dependently. L-arginine (80 mg), but not D-arginine (80 mg), reversed the inhibitory effect of L-NAME (0.8 mg). NA-induced increase in BAT temperature was also decreased by L-NAME. These results suggest that nitric oxide mediates NA-induced increase in BAT blood flow.