Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lateralizing signs in intractable partial epilepsy: blinded multiple-observer analysis

M W Chee1, P Kotagal, P C Van Ness

  • 1Department of Neurology, Cleveland Clinic Foundation, OH 44195.

Neurology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.

Gut·2009
Same author

The functional outcome and recovery of patients admitted to an intensive care unit following drug overdose: a follow-up study.

Anaesthesia and intensive care·2009
Same author

Traveller health: prevalence of diabetes, pre diabetes and the metabolic syndrome.

Irish medical journal·2009
Same author

The prevalence and distribution of Mycobacterium bovis infection in European badgers (Meles meles) as determined by enhanced post mortem examination and bacteriological culture.

Research in veterinary science·2009
Same author

Effects of estrogen therapy on age-related differences in gray matter concentration.

Climacteric : the journal of the International Menopause Society·2009
Same author

Neuroleptics in the treatment of aggressive challenging behaviour for people with intellectual disabilities: a randomised controlled trial (NACHBID).

Health technology assessment (Winchester, England)·2009
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Analyzing seizure behaviors, this study found that specific ictal and postictal signs accurately lateralize the epileptogenic region (ER) in epilepsy patients. These lateralizing signs offer valuable clinical information for diagnosis and treatment planning.

Area of Science:

  • Clinical Neurology
  • Epilepsy Surgery
  • Neurophysiology

Background:

  • Accurate localization of the epileptogenic region (ER) is crucial for successful epilepsy surgery.
  • Behavioral changes during and after seizures can provide lateralizing information.
  • Interobserver reliability of these behavioral signs needs objective evaluation.

Purpose of the Study:

  • To assess the accuracy and interobserver variability of specific ictal and postictal behavioral changes in lateralizing the ER.
  • To determine the positive predictive value (PPV) of observed lateralizing signs.
  • To evaluate the utility of these signs in patients undergoing epilepsy surgery.

Main Methods:

  • Three blinded observers analyzed videotapes of 166 seizures in 38 epilepsy surgery patients.

Related Experiment Videos

  • Observers identified specific ictal and postictal behavioral signs, blinded to clinical history and EEG.
  • Patients included those with successful temporal lobe or extratemporal resections.

    • Main Results:

    • Lateralizing signs correctly identified the ER in 78% of patients, with a PPV of 94%.
    • High agreement (kappa > 0.68) was observed for version, unilateral mouth deviation, unilateral upper extremity automatisms, and postictal dysnomia.
    • Specific signs like dystonic posturing, postictal dysnomia, and ictal speech were associated with temporal lobe epilepsy.

    Conclusions:

    • Analysis of lateralizing signs demonstrates good interobserver agreement and provides clinically useful information for ER localization.
    • Certain behavioral signs, including dystonic posturing and postictal dysnomia, may suggest a higher likelihood of temporal lobe epilepsy.
    • These findings support the use of behavioral analysis as an adjunct in the pre-surgical evaluation of epilepsy.