Jove
Visualize
Contact Us

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Successful management of a chylothorax in infancy using a pleurectomy.

Pediatric surgery international·2013
Same author

Distribution dynamics of perfluorocarbon delivery to the lungs: an intact rabbit model.

Journal of applied physiology (Bethesda, Md. : 1985)·2003
Same author

The dependency of expiratory airway collapse on pump system and flow rate in liquid ventilated rabbits.

European journal of medical research·2003
Same author

Recurrence after laparoscopic and open Nissen fundoplication: a comparison of the mechanisms of failure.

Surgical endoscopy·2003
Same author

An artificial lung reduces pulmonary impedance and improves right ventricular efficiency in pulmonary hypertension.

The Journal of thoracic and cardiovascular surgery·2001
Same author

Exposure to perflubron is associated with decreased Syk phosphorylation in human neutrophils.

Journal of applied physiology (Bethesda, Md. : 1985)·2001
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 19, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Inflammatory bowel disease

M B Statter1, R B Hirschl, A C Coran

  • 1Department of Surgery and Pediatrics, University of Chicago Pritzker School of Medicine, Wyler Children's Hospital, Illinois.

Pediatric Clinics of North America
|December 1, 1993
PubMed
Summary

Pediatric inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease. Differentiation relies on clinical, radiologic, endoscopic, and histologic evaluations, alongside excluding other causes, guiding treatment and surgical interventions.

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Related Experiment Videos

Last Updated: May 19, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Diagnostics

Background:

  • Pediatric inflammatory bowel disease (IBD) comprises distinct intestinal inflammatory conditions.
  • Ulcerative colitis and Crohn's disease are the primary forms of IBD in children.
  • Accurate differentiation is crucial for effective management.

Purpose of the Study:

  • To outline the diagnostic criteria for differentiating pediatric IBD subtypes.
  • To review the current treatment and surgical management strategies for pediatric IBD.
  • To provide a comprehensive overview of ulcerative colitis and Crohn's disease in pediatric patients.

Main Methods:

  • Comparative analysis of clinical presentations.
  • Review of radiologic and endoscopic findings.
  • Histologic evaluation and differential diagnosis protocols.
  • Assessment of treatment outcomes and surgical interventions.

Main Results:

  • Distinct clinical, radiologic, endoscopic, and histologic features differentiate ulcerative colitis from Crohn's disease in children.
  • Exclusion of alternative causes is a key diagnostic step.
  • Current treatment paradigms and operative interventions are detailed.

Conclusions:

  • Accurate diagnosis of pediatric IBD subtypes is achievable through a multimodal approach.
  • Understanding diagnostic nuances guides appropriate therapeutic and surgical strategies.
  • This review synthesizes key information for managing pediatric inflammatory bowel disease.