Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simulation study of confounder-selection strategies

G Maldonado1, S Greenland

  • 1Division of Environmental and Occupational Health, School of Public Health, University of Minnesota, Minneapolis 55455.

American Journal of Epidemiology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone Mass Loss and Sarcopenia in Ecuadorian Patients.

Journal of aging research·2020
Same author

Clinical Characteristics in Patients with Rheumatoid Arthritis: Differences between Genders.

TheScientificWorldJournal·2019
Same author

Duodenal membranes: a late diagnosis evidenced by foreign bodies.

Oxford medical case reports·2018
Same author

Angular momentum regulation strategies for highly dynamic landing in Parkour.

Computer methods in biomechanics and biomedical engineering·2017
Same author

Two glutathione transferase isoforms isolated from juvenile cysts of Taenia crassiceps: identification, purification and characterization.

Journal of helminthology·2017
Same author

Determination of Vitamin D Status in a Population of Ecuadorian Subjects.

TheScientificWorldJournal·2017
Same journal

Design and procedures for the greenness, cognitive performance and vascular outcomes in the northern Manhattan study (NOMAS-greenness).

American journal of epidemiology·2026
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
See all related articles

Researchers evaluated strategies for adjusting variables in Poisson regression models. The "change-in-estimate" and "equivalence-test-of-the-difference" methods performed best with a 10% threshold, while significance tests favored higher alpha levels.

Area of Science:

  • Epidemiology
  • Biostatistics
  • Statistical Modeling

Background:

  • Investigational strategies for variable adjustment in regression models often rely on data-driven decisions when prior knowledge is limited.
  • Multiplicative Poisson regression models are commonly used for analyzing cohort data, particularly when dealing with count data and exposure relationships.

Purpose of the Study:

  • To compare the performance of various data-driven strategies for deciding whether to adjust for covariates in multiplicative Poisson regression models.
  • To evaluate strategies including change-in-estimate, significance-test-of-the-covariate, significance-test-of-the-difference, equivalence-test-of-the-difference, and a hybrid approach.

Main Methods:

  • Simulation study generating data from 8,100 population structures across multiple sample sizes.

Related Experiment Videos

  • Performance evaluation metrics included bias, mean squared error, and confidence interval coverage rates for different adjustment strategies.
  • Analysis focused on multiplicative Poisson regression models for cohort data.

    • Main Results:

    • All examined strategies demonstrated acceptable performance in at least one variation.
    • The "change-in-estimate" and "equivalence-test-of-the-difference" strategies showed optimal performance when the threshold for estimate difference was set low (10%).
    • Significance testing strategies performed best with alpha levels substantially higher than conventional values (e.g., 0.20).

    Conclusions:

    • The choice of adjustment strategy significantly impacts the reliability of regression model estimates.
    • Low thresholds for "change-in-estimate" and "equivalence-test-of-the-difference" offer robust performance in variable adjustment.
    • Higher alpha levels may be necessary for significance testing strategies to achieve acceptable performance in this context.