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Biochemical changes after a 100 km hill walk

M Robertshaw1, R Swaminathan

  • 1Department of Chemical Pathology, Chinese University of Hong Kong, Shatin, N.T.

Journal of Medicine
|January 1, 1993
PubMed
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A 100 km hill walk caused significant biochemical changes, including muscle damage and increased protein breakdown, in participants. These findings highlight the physiological stress of extreme endurance exercise.

Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Sports Medicine

Background:

  • Understanding the physiological impact of extreme endurance events is crucial.
  • Biochemical markers can indicate stress on the body during prolonged physical exertion.

Purpose of the Study:

  • To investigate biochemical alterations in plasma following a 100 km hill walk.
  • To assess markers of muscle damage, protein breakdown, and hydration status.

Main Methods:

  • Blood samples were collected from 16 participants before and after a 100 km hill walk.
  • Plasma concentrations of electrolytes, proteins, liver enzymes, and muscle enzymes were analyzed.

Main Results:

  • Post-walk plasma showed decreased potassium, albumin, and total protein.

Related Experiment Videos

  • Elevated phosphate, urea, alanine transaminase (ALT), and bilirubin were observed.
  • Significant increases in creatine kinase (CK) and lactate dehydrogenase (LD) activities, including isoenzymes CKMB and LD1, were noted.

    • Conclusions:

    • The 100 km hill walk induced plasma volume expansion and muscle damage.
    • Evidence suggests increased protein breakdown occurred post-exercise.
    • Biochemical profiles indicate substantial physiological stress from the endurance challenge.