Related Experiment Videos
Ultraviolet solid-state laser (213-nm) photorefractive keratectomy. In vitro study
1Department of Biomedical Engineering, College of Engineering, University of Miami, Coral Gables, FL 33124-0621.
Ophthalmology
|December 1, 1993
Summary
A novel solid-state laser system offers a safer and more compact alternative for photorefractive keratectomy. This 213-nm laser effectively reshapes the cornea, achieving smooth ablation and good visual outcomes.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Laser Physics
Background:
- Current photorefractive keratectomy relies on argon fluoride excimer lasers, posing hazards and requiring large equipment.
- Solid-state laser alternatives in the far-ultraviolet spectrum offer potential safety and size benefits.
Purpose of the Study:
- To investigate corneal reshaping using a frequency-quintupled neodymium:YAG laser (213 nm).
- To evaluate the efficacy and safety of a solid-state laser system for photorefractive keratectomy.
Main Methods:
- Utilized a 213-nm pulsed neodymium:YAG laser with a computer-controlled optical scanning delivery system.
- Ablated human cadaver and rabbit corneas at a radiant exposure of 250 mJ/cm2.
- Assessed corneal surface changes using topography and microscopy (light, SEM, TEM).
Main Results:
- Achieved myopic corrections from 2.3 to 6.1 diopters.
- Demonstrated a smoothly ablated corneal surface without haze or recognizable steps.
- Observed surface quality and cellular effects comparable to excimer laser photorefractive keratectomy.
Conclusions:
- A 213-nm solid-state laser system can effectively reshape the cornea with smooth transitions.
- The scanning beam delivery system allows for customized, spatially resolved corrections.
- This technology may enhance visual quality after photorefractive keratectomy.