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Long-term studies using a calcium-free dialysate

M Kaye1

  • 1Division of Nephrology, Montreal General Hospital, Quebec, Canada.

Clinical Nephrology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Calcium-free dialysate is safe for long-term hemodialysis. A replacement dose of 13.3 mmol/hour calcium is recommended for optimal patient outcomes and safety.

Area of Science:

  • Nephrology
  • Renal Replacement Therapy
  • Mineral and Bone Disorder

Background:

  • Standard hemodialysis uses dialysate with calcium, which can lead to calcium imbalances.
  • Calcium-free dialysate offers an alternative approach to managing calcium levels during hemodialysis.

Purpose of the Study:

  • To evaluate the long-term safety of calcium-free dialysate in hemodialysis.
  • To determine the optimal calcium replacement dosage for this technique.

Main Methods:

  • A prospective controlled study comparing calcium-free dialysate with standard bicarbonate dialysate.
  • Two groups received different calcium replacement doses (10 mmol/hour and 13.3 mmol/hour) during six-month calcium-free periods.
  • Compared with pre- and post-experimental periods and a concurrent control group.

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Main Results:

  • No adverse effects were observed with calcium-free dialysate.
  • 10 mmol/hour calcium replacement showed a non-significant rise in parathyroid hormone (PTH).
  • 13.3 mmol/hour calcium replacement demonstrated significantly less post-dialysis calcium rise and a slight fall in pre-dialysis calcium.

Conclusions:

  • Calcium-free dialysate is safe for extended use in hemodialysis.
  • 13.3 mmol/hour is an effective calcium replacement dose with Discap 140 dialyzers or equivalent.