[Immunoscintigraphy of human pancreatic cancer an experimental study]

A monoclonal antibody against human pancreatic carcinoma APCA-1, was developed. By immunohistochemical staining, it had pretty good reactivity to carcinoma of the pancreas, bile duct and gall bladder. Their positive rates were 94.1%, 80% and 75%, respectively. It cross reacted weakly with normal epithelial cells of the pancreas, gall bladder and bile duct in relatively low frequency. Immunoscintigraphy was performed in nude mice with xenograft of human pancreatic cancer using 131I-labeled APCA. Good radio-imaging of the tumor xenograft was achieved. The ratio of radioactivity of each gram of tumor tissue to total radioactivity reached 5.1%, 6.9% and 6.2% at 72,120 and 168 hr respectively.