Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of human tissue specimens obtained by directional atherectomy to study restenosis.

Trends in cardiovascular medicine·2011
Same author

Laser Raman spectroscopy of atherosclerotic lesions in human coronary artery segments.

Applied optics·2010
Same author

Laser Raman spectroscopy of calcified atherosclerotic lesions in cardiovascular tissue.

Applied optics·2010
Same author

The epidemiology of melioidosis in the Balimo region of Papua New Guinea.

Epidemiology and infection·2007
Same author

Natural origins of off-flavours in fish related to feeding habits.

Water science and technology : a journal of the International Association on Water Pollution Research·2007
Same author

Necrotizing fasciitis in captive juvenile Crocodylus porosus caused by Streptococcus agalactiae: an outbreak and review of the animal and human literature.

Epidemiology and infection·2007
Same journal

The surgical collateralization theory: has the beautiful hypothesis been killed by the ugly facts?

European heart journal·2026
Same journal

Beyond single measurement: additional considerations for high-sensitivity C-reactive protein in cardiovascular risk prediction.

European heart journal·2026
Same journal

Brain mineralocorticoid receptor activation and antagonism in heart failure with preserved ejection fraction: a hypothesis.

European heart journal·2026
Same journal

Myths and misconceptions about high-sensitivity C-reactive protein as a marker of residual inflammatory risk.

European heart journal·2026
Same journal

Vascular Ehlers-Danlos syndrome: should we treat asymptomatic patients?

European heart journal·2026
Same journal

Impactful trials on dyslipidaemias, fractional flow reserve, beta-blockers, and peripheral artery disease.

European heart journal·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation
06:02

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

Published on: June 10, 2011

Excimer laser-induced vasoreactivity

M Mosseri1, J G Pickering, S Chokshi

  • 1Department of Medicine (Cardiology), St Elizabeth's Hospital, Tufts University School of Medicine, Boston, MA.

European Heart Journal
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Longer pulse duration excimer lasers used in cardiovascular procedures cause unpredictable vascular responses. Shortening pulse trains may reduce the risk of laser-induced vasoconstriction during angioplasty.

More Related Videos

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
09:56

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model

Published on: January 21, 2018

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Related Experiment Videos

Last Updated: Jun 23, 2026

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation
06:02

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

Published on: June 10, 2011

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
09:56

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model

Published on: January 21, 2018

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Laser Medicine

Background:

  • Earlier excimer lasers (≤15 ns pulses) induced vasorelaxation in vitro.
  • Current cardiovascular excimer lasers have longer pulse durations (up to 220 ns) for fiberoptic transmission.
  • Arterial spasm is observed in patients undergoing percutaneous revascularization with these lasers.

Purpose of the Study:

  • Investigate the effect of 'stretched pulse' excimer laser irradiation on vasomotor reactivity.
  • Determine if laser pulse duration influences vascular smooth muscle response.
  • Correlate in vitro findings with clinical observations of arterial spasm.

Main Methods:

  • Used 69 New Zealand white rabbit aorta rings in Krebs buffer.
  • Exposed rings to 308 nm excimer laser with 120 ns pulse duration.
  • Tested responses with and without pharmacological pre-treatment (norepinephrine or nitroglycerin).

Main Results:

  • Without pre-treatment, laser response was variable (vasoconstriction, vasorelaxation, or heterogeneous).
  • Consistent vasorelaxation occurred with norepinephrine pre-contraction (100%).
  • Consistent vasoconstriction occurred with nitroglycerin pre-relaxation (100%).

Conclusions:

  • Long-pulse excimer lasers induce unpredictable, heterogeneous vasomotor responses in vitro.
  • Findings align with clinical observations of unpredictable vascular spasm during laser angioplasty.
  • Abridged pulse trains may reduce laser-induced vasoconstriction in cardiovascular applications.