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Chrysotherapy. A prospective study

N O Rothermich, V K Philips, W Bergen

    Arthritis and Rheumatism
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Chrysotherapy is a valuable treatment for rheumatoid arthritis. A study found that slow-release gold salts (thioglucose) are more effective and safer than fast-release gold salts (thiomalate), with higher dosages showing improved outcomes.

    Area of Science:

    • Rheumatology
    • Clinical Pharmacology

    Background:

    • Chrysotherapy, a gold-based treatment, has been used for rheumatoid arthritis.
    • Traditional approaches to chrysotherapy require reevaluation with modern clinical insights.

    Purpose of the Study:

    • To compare standard weekly dosages of chrysotherapy with weight-based dosing.
    • To evaluate the efficacy and safety of different gold salt formulations (aqueous thiomalate vs. oil repository thioglucose).
    • To explore the impact of higher chrysotherapy dosages on non-responders.

    Main Methods:

    • A 4-year prospective clinical study.
    • Comparison of fixed weekly dosage (50 mg) versus 1 mg/kg body weight.
    • Assessment of rapidly absorbed aqueous thiomalate against slowly absorbed oil repository thioglucose.

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  • Evaluation of patient response and side effects.

    • Main Results:

    • No significant difference was observed between standard and weight-based dosing.
    • Slowly absorbed oil repository thioglucose resulted in significantly fewer side effects and improved outcomes compared to aqueous thiomalate.
    • Increasing dosage in non-responders led to satisfactory clinical responses in 43% without increased toxicity.

    Conclusions:

    • Chrysotherapy remains a valuable and safe treatment for rheumatoid arthritis.
    • Oil repository thioglucose offers a superior safety and efficacy profile over aqueous thiomalate.
    • Higher dosages may benefit non-responders, warranting further investigation despite variations from traditional practices.