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An outbreak of Serratia marcescens infection among obstetric patients
1Christian Medical College & Hospital, Vellore.
Abstract:
An outbreak of S. marcescens infection occurred among 17 obstetric patients during May-June 1990. Simultaneously 11 newborns were also affected. All the 28 strains were identical in their biochemical characteristics, serotype and phage type as well as antimicrobial susceptibility pattern. The source of infection was traced to a contaminated batch of cream, consisting of 0.5 per cent savlon in carboxy methyl cellulose base, used while doing pelvic examination. The affected patients were treated with appropriate antibiotics and there was no mortality. No further infection was reported after the removal of the contaminated cream.
Insights
A Serratia marcescens outbreak affected 28 obstetric patients and newborns. The infection was traced to a contaminated vaginal cream, but prompt antibiotic treatment and removal of the source prevented mortality.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- An outbreak of Serratia marcescens (S. marcescens) infection occurred in obstetric patients and newborns.
- This outbreak highlights the potential for healthcare-associated infections originating from contaminated medical products.
Purpose of the Study:
- To identify the source and characteristics of the S. marcescens outbreak.
- To describe the clinical presentation and management of affected patients.
Main Methods:
- Epidemiological investigation to trace the source of infection.
- Microbiological analysis of clinical isolates, including biochemical characterization, serotyping, phage typing, and antimicrobial susceptibility testing.
- Clinical data review for affected patients.
Main Results:
- Identical S. marcescens strains were isolated from all 28 affected individuals (17 obstetric patients and 11 newborns).
- The source was identified as a contaminated batch of vaginal cream (0.5% savlon in carboxy methyl cellulose base) used during pelvic examinations.
- Affected patients received appropriate antibiotic therapy, and no mortality was reported.
Conclusions:
- Contaminated vaginal cream was the source of the S. marcescens outbreak.
- Prompt identification and removal of the contaminated product, coupled with appropriate antibiotic treatment, effectively controlled the outbreak and prevented further cases or fatalities.