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Related Experiment Videos

Neonatal morbidity between 34 and 37 weeks' gestation

M D Fox1, J R Allbert, J F McCaul

  • 1Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.

Journal of Perinatology : Official Journal of the California Perinatal Association
|September 1, 1993
PubMed
Summary

Magnesium tocolysis for preterm labor between 34 and 37 weeks did not reduce neonatal complications. The costs and risks of tocolysis outweigh unproven infant benefits, indicating conservative management is sufficient.

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Perinatology

Background:

  • Preterm labor between 34 and 37 weeks' gestation presents a clinical dilemma regarding intervention.
  • The potential benefits of tocolysis in this gestational window for neonatal outcomes are not well-established.

Purpose of the Study:

  • To assess the risk of significant neonatal morbidity in women delivering between 34 and 37 weeks' gestation following preterm labor.
  • To compare neonatal outcomes between intravenous magnesium tocolysis and conservative management.

Main Methods:

  • A randomized controlled trial involving 90 women with preterm labor between 34-37 weeks' gestation.
  • Participants were assigned to either intravenous magnesium tocolysis or conservative management (hydration, sedation, observation).

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  • Neonatal complications were monitored and compared between the two groups.

    • Main Results:

    • No significant difference in gestational age, cervical dilation, interval to delivery, or birth weight between groups.
    • No serious neonatal complications were observed in either group.
    • Transient tachypnea occurred in three women and respiratory distress syndrome in one woman in each group.

    Conclusions:

    • Neonatal morbidity is not significantly altered by tocolytic therapy in preterm labor between 34 and 37 weeks' gestation.
    • The expense and maternal risks associated with tocolysis are not justified by the lack of demonstrated infant benefit.
    • Conservative management appears sufficient for pregnancies delivering in this gestational window.