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[Treatment of hematogenic osteomyelitis in newborns]
Insights
Direct immune hemotransfusions and bone marrow transplantation improved newborn osteomyelitis treatment outcomes. This approach enhanced cellular and humoral immunity, leading to bone structure restoration and fewer orthopedic complications.
Area of Science:
- Pediatric Hematology
- Immunology
- Orthopedic Surgery
Background:
- Acute hematogenous osteomyelitis is a significant concern in newborns.
- Understanding the immunobiological response is crucial for effective treatment strategies.
Observation:
- The study examined 215 newborns with acute hematogenous osteomyelitis, primarily affecting long bone metaphyses and epimetaphyses.
- Treatment involved direct immune hemotransfusions and bone marrow transplantation with stroma and antibiotics into the infected site.
Findings:
- Treatment demonstrated favorable immediate and long-term results, evidenced by radiological bone structure restoration.
- Immunological markers indicated an increase in both cellular and humoral immunity post-treatment.
- Late-term follow-up revealed a reduction in orthopedic complications.
Implications:
- This combined therapeutic approach shows promise for improving outcomes in neonatal osteomyelitis.
- Enhancing immune function appears critical for successful bone healing and complication reduction.
- Further research can explore optimizing these immunomodulatory strategies for pediatric bone infections.
Abstract:
The authors studied the immunobiological condition of the newborn's organism and the process of bone structure reparation before and after direct immune hemotransfusions and transplantation of bone marrow with the stroma in a mixture with antibiotics into the focus of osteomyelitis in the bone of newborn infants with consideration for the clinical manifestations of the disease, the stage of osteomyelitis, and the efficacy of the applied treatment. The authors examined 215 newborns with acute hematogenous osteomyelitis. The predominant site of localization of acute hematogenous osteomyelitis in the newborn infants were the epimetaphyseal (54.5%) and metaphyseal (39.6%) parts of the long tubular bones. The donors were immediate relatives compatible according to the ABO system and the rhesus factor, who underwent complete examination for HIV infection, the Australia antigen, and the Wasserman reaction, and who were immunized preliminarily with the staphylococcus anatoxin. The authors note the favorable immediate and late-term results of treatment which were confirmed by radiological restoration of the bone structure. The immunological values testify to increase of cellular and humoral immunity. Study of the late-term results of treatment confirm the decrease of the number of orthopedic complications.