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Modulation of hepatic fibrogenesis by antioxidants
G Poli1, M Parola, G Leonarduzzi
1Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.
Molecular Aspects of Medicine
|January 1, 1993
Abstract:
The oxidative damage of liver tissue appears to favour a fibrogenic process, through the stimulation of TGF beta 1 and procollagen gene expression. The latter effect has been also showed by a well defined end-product of lipid peroxidation, 4-hydroxy-2,3-nonenal in human Ito cell culture. "In vivo" and "in vitro" data give evidence of a strong down modulation of TGF beta 1 and collagen expression afforded by supplementation with different antioxidant molecules.