Effect of intraperitoneal administration of zinc in C57/6J mice

Intraperitoneal administration of zinc chloride to C57/6J mice in vivo at 28 micrograms/g body weight was more lethal to the male mice and induced growth retardation in the male and female survivors. In the group of experimental survivors, the weight of the lungs were significantly decreased compared with the control animals. The inherent dangers of zinc excess is highlighted, especially with regard to the possibility of cumulative zinc toxicity.