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Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study
R B D'Agostino1, P A Wolf, A J Belanger
1Department of Mathematics, Boston University, MA 02215.
Stroke
|January 1, 1994
Summary
Modified stroke risk prediction models now better assess antihypertensive medication effects. These updated functions improve the evaluation of 10-year stroke risk and guide risk factor modification strategies.
Area of Science:
- Cardiology
- Neurology
- Epidemiology
Background:
- Existing sex-specific health risk appraisal functions for stroke prediction were based on the Framingham Study cohort.
- These functions utilized Cox proportional hazards regression models incorporating various risk factors including age, blood pressure, and medication use.
Purpose of the Study:
- To modify existing stroke risk prediction functions to enhance the assessment of antihypertensive medication effects.
- To develop more accurate models for predicting first stroke, particularly considering the impact of blood pressure management.
Main Methods:
- Adjusted Cox proportional hazards regression models based on Framingham Study data.
- Incorporated a refined understanding of antihypertensive therapy's effect, specifically within a systolic blood pressure range of 110-200 mm Hg.
- Tested statistical significance and goodness-of-fit for the modified regression models.
Main Results:
- Developed modified health risk appraisal functions that demonstrate improved consistency with observed data.
- Generated updated tables for evaluating 10-year risk of first stroke based on the refined models.
Conclusions:
- The enhanced stroke profile provides a more accurate tool for risk evaluation and suggests effective risk factor modification strategies.
- The updated functions allow for a better assessment of antihypertensive therapy's role in stroke risk evaluation.