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Effects of oxygen radicals, hydrogen peroxide and water-soluble singlet oxygen carriers on 5- and 12-lipoxygenase
Archiv Der Pharmazie
|October 1, 1993
Abstract:
Inhibition of 5-lipoxygenase from bovine polymorphonuclear leukocytes and 12-lipoxygenase from bovine platelets by active oxygen species has been studied. Oxygen radicals and hydrogen peroxide markedly inhibited 12-lipoxygenase, whereas 5-lipoxygenase activity was only moderately influenced. Singlet oxygen liberated from water-soluble naphthalene endoperoxides was without effect.