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[Oxidative phosphorylation uncoupling by fatty acids in liver and muscle mitochondria]
E N Mokhova1, A A Starkov, V A Bobyleva
1Istituto di Patologia Generale, Universita degli Study di Modena, Italy.
Biokhimiia (Moscow, Russia)
|October 1, 1993
Abstract:
Pathways and mechanisms of oxidative phosphorylation uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) uncoupling due to the low protonophoric activity of fatty acids.