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A novel surface photo-graft polymerization method for fabricated devices
Y Nakayama1, T Matsuda, M Irie
1Department of Bioengineering, National Cardiovascular Center Research Institute, Osaka, Japan.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1993
Summary
A novel photo-graft polymerization technique enables precise surface modification of complex devices. This method utilizes dithiocarbamate chemistry for controlled polymerization, allowing for micron-level patterning and cell culture applications.
Area of Science:
- Polymer Chemistry
- Materials Science
- Surface Engineering
Background:
- Surface modification is crucial for advanced materials and devices.
- Controlling graft polymerization on complex shapes presents significant challenges.
- Existing methods often lack precision and control over grafted polymer properties.
Purpose of the Study:
- To introduce a new photo-graft polymerization method for complex surfaces.
- To demonstrate precise control over molecular weight and spatial patterning.
- To showcase the application of this technique in cell culture patterning.
Main Methods:
- Utilizing dithiocarbamate-based photochemistry as a living radical polymerization iniferter.
- Coating substrates with a photosensitive copolymer followed by UV irradiation and monomer exposure.
- Employing quartz crystal microbalance (QCM) for quantitative monitoring of graft polymerization.
- Demonstrating 2D cell patterning with micron-order precision.
Main Results:
- Successful surface graft polymerization of N,N-dimethylacrylamide onto poly(ethylene terephthalate).
- Achieved controlled molecular weight of grafted polymers due to living radical polymerization.
- Demonstrated micron-scale spatial control of polymerization via UV light patterning.
- Verified polymerization weight increase with ng-order sensitivity using QCM.
Conclusions:
- The developed photo-graft polymerization method offers precise control over surface modification.
- This technique is suitable for creating complex, patterned surfaces on various devices.
- The method holds potential for advanced applications in biomaterials and microfluidics.