Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small diameter vascular prostheses with incorporated bioabsorbable matrices. A preliminary study

S Niu1, H Kurumatani, S Satoh

  • 1Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nightlife clusters of coronavirus disease in Tokyo between March and April 2020.

Epidemiology and infection·2020
Same author

Development and validation of the comprehensive assessment scale for chemotherapy-induced peripheral neuropathy in survivors of cancer.

BMC cancer·2019
Same author

A Double-blind, Placebo-controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease.

Journal of veterinary internal medicine·2017
Same author

Relationships between Tyrosinase Activity and Gill Browning during Preservation of Lentinus edodes Fruit-bodies.

Bioscience, biotechnology, and biochemistry·2016
Same author

Phage-inactivating Effect of Iron(II)-Ascorbate Complex.

Bioscience, biotechnology, and biochemistry·2016
Same author

Regulation of L-alanine-initiated germination ofBacillus subtilis spores by alanine racemase.

Amino acids·2013

This study developed small vascular grafts using a gelatin-heparin complex, showing adequate cross-linking promotes neointima formation and maintains patency. These bioabsorbable vascular prostheses offer a promising solution for vascular reconstruction.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Small diameter vascular prostheses are crucial for replacing damaged arteries.
  • Achieving long-term patency and promoting host tissue integration remains a challenge.
  • Developing bioabsorbable materials that support neointima formation is essential.

Purpose of the Study:

  • To design and evaluate small diameter vascular prostheses with incorporated, bioabsorbable matrices.
  • To investigate the effect of cross-linking duration on graft performance and host tissue response.
  • To assess the antithrombogenic properties and neointima formation of gelatin-heparin complex-coated polyester grafts.

Main Methods:

  • Gelatin-heparin complex coating on polyester fabric grafts presealed with albumin.

Related Experiment Videos

  • Cross-linking grafts with polyepoxy compounds for 3 days (Group I) or 5 days (Group II).
  • Implantation into carotid arteries of mongrel dogs and evaluation of patency, histology, and scanning electron microscopy.

    • Main Results:

    • Graft patency rates were 75% at 4 weeks (Group I) and 75% at 8 weeks (Group II).
    • No platelet aggregation or fibrin formation observed on the midportion of grafts in either group.
    • Group I showed thin neointima over absorbed gelatin-heparin and well-formed connective tissue; Group II had thick neointima over remaining gelatin-heparin.

    Conclusions:

    • Adequately cross-linked gelatin-heparin complex functions as a temporary antithrombogenic surface.
    • The complex serves as an excellent substructure for anastomotic neointima formation.
    • These bioabsorbable vascular prostheses demonstrate potential for successful vascular reconstruction.