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Synthesis and antibacterial activity of new 2-substituted penems. I
T Nishi1, K Higashi, M Takemura
1Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|November 1, 1993
Abstract:
A new type of penem derivative (3-6) having a cyclic amidine moiety or a quaternary heterocycle moiety at the C-2 position was prepared. The susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. Some of these compounds (5,6) showed a broad spectrum of antibacterial activity, including activity against Pseudomonas aeruginosa.