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The cancer anorexia-cachexia syndrome

K A Nelson1, D Walsh, F A Sheehan

  • 1Department of Hematology/Medical Oncology, Cleveland Clinic Foundation, OH 44195.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|January 1, 1994
PubMed
Summary

Anorexia-cachexia syndrome is common in advanced cancer patients. While the exact cause remains unknown, clinical evaluation can identify patients who may benefit from symptomatic treatments.

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Area of Science:

  • Oncology
  • Metabolic Disorders

Background:

  • Anorexia-cachexia syndrome (ACS) is a complex multifactorial condition frequently observed in patients with advanced cancer.
  • It significantly impacts patient quality of life and treatment outcomes.
  • Understanding the etiology and management of ACS is crucial in cancer care.

Purpose of the Study:

  • To conduct a comprehensive review of existing research on anorexia-cachexia syndrome in cancer patients.
  • To focus on the underlying causes (etiology) and available symptomatic treatments for ACS.

Main Methods:

  • A thorough literature search was performed using the MEDLINE database.
  • The review synthesized findings from relevant published studies.

Main Results:

  • Anorexia-cachexia syndrome is a prevalent issue in patients diagnosed with advanced cancer.
  • Despite extensive research into potential causes, a definitive etiology has not yet been established.
  • Identifying patients who could respond to current symptomatic therapies requires careful clinical assessment.

Conclusions:

  • Anorexia-cachexia syndrome presents a significant clinical challenge in advanced cancer management.
  • Further research is needed to elucidate the precise mechanisms driving ACS.
  • Personalized clinical evaluation is essential for optimizing symptomatic treatment strategies.

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