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Adrenoleukodystrophy in France: an epidemiological study
C Sereni1, M Paturneau-Jouas, P Aubourg
1INSERM U-134, Neurobiologie Cellulaire, Moléculaire et Clinique, Hôpital de la Salpêtrière, Paris, France.
Neuroepidemiology
|January 1, 1993
Summary
Adrenoleukodystrophy (ALD), a severe X-linked neurologic disorder, affects boys and young men. The lowest estimated prevalence in France is 1 in 100,000 male births, based on cases from 1956-1986.
Area of Science:
- Neurology
- Genetics
- Epidemiology
Background:
- Adrenoleukodystrophy (ALD) is a severe, X-linked neurologic disorder.
- It primarily affects boys and young men, leading to progressive disability.
Purpose of the Study:
- To estimate the prevalence of adrenoleukodystrophy in France.
- To provide a baseline for understanding the incidence of this rare genetic disorder.
Main Methods:
- An epidemiological study was conducted in France.
- Data from 129 collected cases born between 1956 and 1986 were analyzed.
- Clinical history was reviewed to determine prevalence.
Main Results:
- The lowest estimated prevalence of adrenoleukodystrophy was calculated.
- The estimated prevalence is 1 in 100,000 male births.
Conclusions:
- Adrenoleukodystrophy affects approximately 1 in 100,000 males.
- This study provides crucial epidemiological data for a rare X-linked neurologic condition.