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Biological specimen bank for smelter workers
L Gerhardsson1, D Brune, N G Lundström
1Department of Environmental Medicine, University of Umeå, Sweden.
The Science of the Total Environment
|November 1, 1993
Summary
This study established a biological specimen bank to track trace elements in human organs, focusing on occupational exposure in Swedish smelter workers. Findings help assess environmental health risks and reevaluate exposure limits.
Area of Science:
- Environmental Medicine
- Toxicology
- Occupational Health
Background:
- Established in 1975 at the University of Umeå, the biological specimen bank collects human organ samples.
- Focuses on trace element analysis, particularly concerning occupational exposure.
- Utilizes samples from deceased copper and lead smelter workers and control individuals.
Purpose of the Study:
- To gather data on trace elements in human organs.
- To investigate the influence of occupational exposure on trace element levels.
- To provide data for risk assessment and reevaluation of threshold limit values.
Main Methods:
- Collection of tissue samples (lung, liver, kidney, bone, brain, etc.) from workers and controls.
- Use of specialized instruments (quartz) and storage vessels (quartz ampoules, polyethene vessels) to prevent contamination.
- Analysis of elements (Sb, As, Cd, Cr, Co, La, Se, Pb, Zn) using neutron activation analysis and atomic absorption spectrophotometry.
Main Results:
- Established a long-term biological specimen bank for trace element research.
- Collected and analyzed human tissue samples to quantify specific elements.
- Enabled correlation of findings with occupational exposure, normal tissue values, and causes of death.
Conclusions:
- The bank provides valuable data for understanding trace element accumulation due to occupational exposure.
- Findings support the reevaluation of occupational exposure limits and risk assessment.
- Longitudinal data analysis is crucial for tracking trends and impacts over time.