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X-linked agammaglobulinemia--gene cloning and future prospects
C Kinnon1, S Hinshelwood, R J Levinsky
1Molecular Immunology Unit, University of London, UK.
Immunology Today
|November 1, 1993
Abstract:
The btk gene has recently been identified as the causative gene in X-linked agammaglobulinemia (XLA). This has opened up many new possibilities for the treatment of this B-cell immunodeficiency. Christine Kinnon and colleagues review the high degree of sequence of homology of btk to the non-receptor tyrosine kinases and speculate on putative roles for this gene in B-cell development.