Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Portal high flow state in dogs]

Y T Huang1

  • 1First Teaching Hospital, Beijing Medical University.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|April 1, 1993
PubMed
Summary

This study created a canine model of high portal blood flow using a portacaval shunt (PCS). Results show high portal flow alone does not cause portal hypertension, highlighting portal resistance as the key factor.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Associations of waist-to-hip ratio with mortality in older adults in 10 areas of China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[A case of left ventricular apical hypoplasia].

Zhonghua xin xue guan bing za zhi·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

Enhanced S-Factor for the ^{14}N(p,γ)^{15}O Reaction and Its Impact on the Solar Composition Problem.

Physical review letters·2025
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

[RAF1 rearranged spindle cell tumor: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2025

Area of Science:

  • Veterinary Medicine
  • Surgical Innovation
  • Gastroenterology

Context:

  • Developing animal models is crucial for understanding complex physiological conditions.
  • Portal hypertension is a serious clinical condition with significant morbidity.
  • Previous models may not accurately replicate the hemodynamics of portal hypertension.

Purpose:

  • To develop a reliable animal model simulating high portal blood flow.
  • To investigate the hemodynamic and pathological consequences of sustained portal hypervolemia.
  • To differentiate the roles of portal flow and resistance in portal hypertension development.

Summary:

  • A retrograde portacaval shunt (PCS) was created in 11 dogs to induce sustained portal hypervolemia.
  • Portal hemodynamics were monitored, and liver pathology assessed post-operation.
  • The model maintained high portal flow without significant collateral circulation or liver damage, indicating flow alone doesn't cause hypertension.

Impact:

  • This model provides a valuable tool for studying conditions involving altered portal hemodynamics.
  • Findings suggest that increased portal resistance, not just high flow, is the critical initiator of clinical portal hypertension.
  • The research clarifies the pathophysiology of portal hypertension, potentially guiding future therapeutic strategies.

Related Experiment Videos