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Monitoring the adverse profile of atenolol--a collaborative study
K C Garg1, K C Singhal, S Kumar
1Department of Medicine, Maulana Azad Medical College, New Delhi.
Insights
This study investigated adverse drug reactions (ADR) to atenolol in Indian cardiac patients. ADRs were less frequent than in Western populations, suggesting potential racial or environmental influences.
Area of Science:
- Cardiology
- Pharmacology
- Clinical Research
Background:
- Atenolol is a common beta-blocker for cardiac conditions.
- Its adverse drug reaction (ADR) profile in Indian patients requires further investigation.
Purpose of the Study:
- To monitor and analyze ADRs associated with atenolol in an Indian patient cohort.
- To compare ADR frequencies in Indian patients with data from Western countries.
Main Methods:
- An open, prospective, collaborative ADR monitoring study.
- Enrolled 440 Indian patients with heart disease, with 435 completing the analysis.
- Data collected from Maulana Azad Medical College and J.N. Medical College.
Main Results:
- Low incidence of ADRs observed: cold extremities (1.18%), headache/dizziness (1.41%), breathlessness (0.94%), edema (0.70%), bradycardia (0.47%).
- ADR rates were lower compared to those reported in Western countries.
- Potential factors for reduced ADRs include patient selection, optimal dosing, racial factors, and season.
Conclusions:
- Atenolol appears to have a favorable ADR profile in the studied Indian population.
- Further research into racial and environmental factors influencing atenolol ADRs is warranted.
- Optimized patient selection and dosing may further minimize ADRs.
Abstract:
Atenolol, a cardio selective beta-adrenergic blocker, frequently prescribed in various cardiac ailments, has not been thoroughly investigated for its adverse reaction profile in Indian patient. The present ADR monitoring study which was open, prospective and collaborative was therefore planned. A total of 440 patients with various heart disease were enrolled after a strict inclusion and exclusion criteria from Maulana Azad Medical College, New Delhi and J.N. Medical College, Aligarh. fifteen patients dropped out leaving 435 for final analysis. Cold extremities occurred in 1.18% headache and dizziness in 1.41% breathlessness in 0.94% oedema in 0.70% and bradycardia in 0.47%. Adverse drug reaction in our study were less than those reported from Western countries. Better patient selection, optimal dose could have reduced the frequency of ADR in the present study. Racial factor and season might be operating to bring down ADR to atenolol in Indian patients.