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Histologic evaluation of chronic human wounds treated with hydrocolloid and nonhydrocolloid dressings
T J Phillips1, M J Palko, J Bhawan
1Department of Dermatology, Boston University Medical Center, MA.
Background:
Studies of acute surgical wounds in pigs have shown granulomatous tissue reactions induced by hydrocolloid dressings.
Objective:
We examined biopsy specimens from chronic wounds in humans treated with hydrocolloid or nonhydrocolloid dressings to determine whether such reactions occurred.
Methods:
A blinded retrospective analysis of 22 chronic ulcer biopsy specimens from 22 patients was performed by two dermatopathologists independently.
Results:
No differences were seen between hydrocolloid-treated and non-hydrocolloid-treated wounds. Granulation tissue was seen in all specimens. No cavities, eosinophilic inclusions, polarizable material, or multinucleated giant cells were identified.
Conclusion:
There are no significant histologic differences between hydrocolloid-treated and non-hydrocolloid-treated wounds in humans.