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Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats
1Departamento de Farmacologia e Psicobiologia, Universidade de Estado do Rio de Janeiro, Brasil.
Pharmacology, Biochemistry, and Behavior
|November 1, 1993
Abstract:
Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens. The T3 antagonized oxotremorine-induced hypothermia and failed to antagonize eserine hypothermic effect, but potentiated oxotremorine- and eserine-induced tremors. Acetylcholinesterase activity was not altered in T3 rats. The hypothetical mechanisms to explain changes of central cholinergic responses caused by T3 are discussed.