[The effect of liposome phospholipids in collagen-induced platelet aggregation]

Influence of the charge-bearing phospholipids containing in liposome membrane on collagen-induced platelet aggregation was studied. The aggregation was inhibited after preincubation of blood platelets with liposomes containing egg lecithin/cholesterol/phosphatidylserine (stearyl amine); the effect was dose-dependent. Phosphatidylinositol incorporated into liposomes did not affect distinctly thrombocytes activation but decreased the rate of cell disaggregation; this effect was also dose-dependent. Use of phosphatidylinositol containing liposomes did not affect the content of thromboxane and prostacyclin in the system. The effect of the charge-bearing phospholipids on platelet aggregation observed should be considered in production of medicinal drugs.