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Pediatric and adolescent oligodendrogliomas

H Tice1, P D Barnes, L Goumnerova

  • 1Department of Radiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.

AJNR. American Journal of Neuroradiology
|November 1, 1993
PubMed
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Pediatric oligodendrogliomas show distinct imaging features compared to adults, with less calcification and contrast enhancement. These brain tumors have a slow growth rate and an excellent prognosis after surgical resection.

Area of Science:

  • Neuro-oncology
  • Pediatric neurosurgery
  • Neuroradiology

Background:

  • Oligodendrogliomas are glial tumors that can occur in children and adolescents.
  • Understanding their specific characteristics in pediatric populations is crucial for diagnosis and treatment.

Purpose of the Study:

  • To review the clinical and imaging findings of pure oligodendrogliomas in pediatric and adolescent patients.
  • To compare these findings with those reported in adult series.

Main Methods:

  • Retrospective review of clinical, CT, and MR data from 39 surgically confirmed pure oligodendrogliomas.
  • Analysis of tumor location, density, signal intensity, calcification, margins, mass effect, edema, and enhancement.

Main Results:

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  • Frontal or temporal lobe involvement in 82% of cases.
  • Commonly hypodense on CT and hypointense on T1-weighted MRI; hyperintense on T2-weighted images.
  • Less frequent calcification (<40%) and contrast enhancement (<25%) compared to adult series.
  • Well-defined margins in nearly 60%, minimal mass effect, and rare edema.
  • Tumor stability observed in follow-up studies over a mean of 5 years post-resection.

Conclusions:

  • Pediatric pure oligodendrogliomas exhibit distinct imaging features, including less calcification, contrast enhancement, and edema than adult counterparts.
  • These tumors often display slow or no growth, indicating a favorable prognosis.
  • Surgical resection is associated with an excellent outcome for pediatric patients with pure oligodendrogliomas.