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Pulmonary function abnormalities in patients with primary Sjögren's syndrome
E Martínez-Cordero1, L Andrade-Ortega, E Martínez-Miranda
1Department of Immunology and Rheumatology, Hospital 20 de Noviembre ISSSTE, México, D.F., México.
Summary
Pulmonary disease is common in primary Sjögren
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Primary Sjögren's syndrome (SS) is a chronic autoimmune disease.
- Pulmonary involvement is a recognized but not fully characterized complication of SS.
Purpose of the Study:
- To determine the frequency and type of pulmonary disease in patients with primary SS.
- To investigate the relationship between pulmonary function abnormalities and specific autoantibodies.
Main Methods:
- Respiratory function tests were performed on 32 patients with primary SS.
- Pulmonary function was assessed for restrictive, obstructive, and mixed patterns.
- Autoantibody profiles (antinuclear antibodies, anti-SS-A(Ro), anti-SS-B(La)) were analyzed in relation to respiratory findings.
Main Results:
- Pulmonary abnormalities were detected in a significant portion of patients.
- Restrictive lung disease was observed in 28.1%, obstructive in 21.8%, and mixed in 25%.
- Anti-SS-A(Ro) and anti-SS-B(La) antibodies were more frequent in patients with restrictive lung disease and correlated with reduced total lung capacity (TLC) and forced vital capacity (FVC).
Conclusions:
- Pulmonary disease is prevalent in primary Sjögren's syndrome.
- Specific autoantibodies, particularly anti-SS-A(Ro) and anti-SS-B(La), are associated with restrictive lung disease and reduced lung volumes in these patients.