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[Pathoanatomical characteristics of pseudotuberculosis in Macaca mulatta]
Abstract:
Pathologo-anatomic investigations of organs of 81 monkeys who had died of pseudotuberculosis were carried out. The disease was characterized by pronounced polymorphism of changes with predominant lesions of the peritoneal cavity organs--the spleen, liver, intestinal and mesenterial lymphatic nodes. Granulomas appeared consisting of reticular cells with admixture of neurophilic, eosinophilic leucocytes with necrosis in the centre. Pseudotuberculosis in monkeys, as to its clinical and patho-anatomic features, has very much in common with that in man, however, in monkeys the disease has a much severer course and with a considerable per cent of fatal outcomes among the diseased animals.
Insights
Pseudotuberculosis in monkeys presents severe, fatal outcomes with widespread lesions, particularly in abdominal organs. Patho-anatomic findings show similarities to human cases but a more aggressive course in primates.
Area of Science:
- Veterinary Pathology
- Primate Medicine
- Infectious Diseases
Context:
- Pseudotuberculosis, a bacterial infection, affects various animal species.
- Monkeys exhibit unique responses to this pathogen.
- Understanding primate-specific disease pathology is crucial for comparative medicine.
Purpose:
- To detail the pathologo-anatomic findings of pseudotuberculosis in 81 deceased monkeys.
- To compare the clinical and pathological features of pseudotuberculosis in monkeys versus humans.
- To highlight the severity and mortality rates of the disease in this primate population.
Summary:
- Pathologo-anatomic investigations revealed pronounced lesions in the spleen, liver, intestinal, and mesenteric lymph nodes of monkeys with pseudotuberculosis.
- Histological examination showed granulomas composed of reticular cells, leukocytes, and central necrosis.
- The disease course in monkeys is significantly more severe than in humans, leading to a considerable percentage of fatalities.
Impact:
- Provides critical insights into primate infectious diseases.
- Enhances understanding of pseudotuberculosis pathogenesis in a non-human primate model.
- Informs veterinary diagnostics and treatment strategies for affected animals.
- Contributes to comparative pathology research between primates and humans.