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Tumor necrosis factor is not involved in exercise-induced elevation in core temperature
P J Rowsey1, K T Borer, M J Kluger
1Division of Kinesiology, University of Michigan, Ann Arbor 48109.
The American Journal of Physiology
|December 1, 1993
Summary
Tumor necrosis factor-alpha (TNF) does not modulate exercise-induced body temperature increases in female rats. Blocking TNF activity did not alter elevated daytime or nighttime temperatures in exercising rats.
Area of Science:
- Physiology
- Exercise Physiology
- Immunology
Background:
- Regular exercise in female rats elevates body temperature during both activity and rest periods.
- Tumor necrosis factor-alpha (TNF) is a cytokine known to influence fever responses.
Purpose of the Study:
- To investigate if TNF modulates exercise-induced body temperature elevation in female rats.
- To determine the role of endogenous TNF in regulating body temperature during exercise and rest.
Main Methods:
- Female Sprague-Dawley rats were subjected to wheel running to induce exercise.
- Rats received injections of antiserum to TNF or control serum.
- Body temperature was monitored during daytime and nighttime periods.
- Fever response was assessed after lipopolysaccharide (LPS) challenge.
Main Results:
- Exercise led to significant increases in both nighttime (0.5°C) and daytime (0.3°C) body temperatures in rats.
- Antiserum to TNF enhanced LPS-induced fever in female rats, confirming TNF's role in fever modulation.
- However, blocking TNF in exercising rats did not affect their elevated daytime or nighttime body temperatures.
Conclusions:
- TNF is not responsible for modulating the exercise-induced rise in body temperature in female rats.
- While TNF plays a role in fever, its involvement in exercise-related thermoregulation in this model is negligible.