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Results from a new renal transplantation unit
Lancet (London, England)
|December 23, 1978
Summary
Kidney transplantation outcomes in Oxford show 70% patient survival at 42 months using standard immunosuppression. Key factors for success include HLA-DR matching and pre-transplant transfusions, establishing a benchmark for renal transplantation practices.
Area of Science:
- Nephrology
- Transplant Surgery
- Immunology
Background:
- Establishment of a renal transplant unit at Oxford.
- Focus on end-stage renal failure treatment.
- Conventional immunosuppressive therapy and minimum-transfusion policy.
Purpose of the Study:
- To report outcomes of 158 kidney transplants.
- Identify significant factors influencing transplant success.
- Establish a benchmark for renal transplantation practices.
Main Methods:
- Analysis of 158 kidney transplants (living related and cadaveric).
- Use of azathioprine and prednisolone for immunosuppression.
- Minimum-transfusion policy implementation.
Main Results:
- Actuarial patient survival of 70% after cadaveric transplantation.
- 85% of patients with functioning grafts achieved full rehabilitation.
- Significant factors: HLA-DR matching, pre-transplant blood transfusions, positive B-cell crossmatch.
Conclusions:
- Kidney transplantation is the primary treatment for end-stage renal failure in patients under 56.
- Conventional immunosuppression and minimum-transfusion policy yield comparable results.
- The study provides a benchmark for evaluating new renal transplantation strategies.