Related Experiment Video
Updated: Aug 15, 2026

11:08
The Indirect Neuron-astrocyte Coculture Assay: An In Vitro Set-up for the Detailed Investigation of Neuron-glia Interactions
Published on: November 14, 2016
[Typical synapses between neurons and oligodendroglial cells in the human cerebral cortex]
Summary
Oligodendroglial cells, the satellite cells of neurons, dynamically adjust to rapid neural messages. This highlights a crucial interplay between glial cells and neuronal function in the brain.
Area of Science:
- Neuroscience
- Cellular Biology
- Glial Cell Biology
Context:
- Investigates the dynamic relationship between neurons and neuroglia.
- Focuses on the role of oligodendroglial cells as neuronal satellites.
Purpose:
- To elucidate the functional significance of synapses in the context of neuron-glia interactions.
- To understand how oligodendroglial cells respond to neuronal activity.
Summary:
- Synaptic transmission involves rapid signaling that prompts adjustments in oligodendroglial cells.
- These glial cells are sensitive to and adapt to the functional state of the neurons they support.
Impact:
- Provides insight into the sophisticated communication networks within the central nervous system.
- Underscores the active role of glial cells in supporting neuronal function and brain plasticity.
More Related Videos
Related Concept Videos
Glial Cells
Overview
The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Nervous Tissue: Myelin
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Overview of Synapses
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
Nervous Tissue: Glial Cells
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

