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Investigations of oligodeoxyinosine for triple helix formation
1Department of Chemistry, Oregon State University, Corvallis 97331.
Antisense Research and Development
|January 1, 1993
Abstract:
The ability of a 17-mer of deoxyinosine to form a triple helix with a (dT)17(dA)17 segment of a 29-mer Watson-Crick duplex was investigated. Under conditions amenable to triple helix formation, (dT)17 showed evidence of complex formation as evidenced by UV melting curves and gel mobility shift assays whereas (dI)17 did not.