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Women's opinion on withdrawal bleeding with hormone replacement therapy
R Barentsen1, F P Groeneveld, F P Bareman
1Department of Obstetrics, Elkerliek Hospital, Helmond, The Netherlands.
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|October 29, 1993
Summary
Many premenopausal women accept hormone replacement therapy (HRT) with periodic bleeding, preferring quarterly cycles. Postmenopausal women largely object to HRT withdrawal bleeds, necessitating research into non-bleeding regimens.
Area of Science:
- Gynecology
- Reproductive Health
- Menopause Management
Background:
- Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
- Continuation or re-induction of bleeding periods during HRT is a debated aspect.
- Understanding women's opinions on HRT-associated bleeding is crucial for treatment adherence.
Purpose of the Study:
- To assess women's opinions on hormone replacement therapy (HRT).
- To evaluate acceptance of continued or re-induced bleeding periods with HRT.
- To compare preferences for monthly versus trimonthly withdrawal bleeding schedules.
Main Methods:
- Population-based cross-sectional study.
- Utilized a postnatal questionnaire in Krimpen aan den IJssel, Netherlands.
- Surveyed 2729 women aged 45-60 years, with 1947 (71.3%) responding.
Main Results:
- 16.9% of all women had no/little objection to monthly withdrawal bleeds with HRT.
- Premenopausal women (32.4%) were more accepting of monthly bleeds than postmenopausal women (9.2%).
- Trimonthly cycles were more acceptable: 41.4% of premenopausal and 11.8% of postmenopausal women had no/little objection.
Conclusions:
- A significant proportion of premenopausal women accept periodic bleeding with HRT.
- Trimonthly HRT cycles are preferred over monthly ones.
- Most postmenopausal women object to withdrawal bleeds, indicating a need for HRT schedules without bleeding.