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Lichen planus associated with neoplasia: a cell-mediated immune response to tumor antigens?
Journal of the American Academy of Dermatology
|February 1, 1994
Abstract
Background:
Individual case reports have suggested an occasional association of lichen planus with internal malignancy.
Objective:
Our purpose was to describe five patients with a neoplastic disease in whom lichen planus developed.
Methods:
Serologic and immunopathologic studies were conducted.
Results:
No evidence of autoantibody production characteristic of paraneoplastic pemphigus was found, and antibodies reactive with basal cell keratinocytes were not detected.
Conclusion:
Lichen planus may be rarely induced by neoplasia. A cell-mediated immune reaction possibly causes this phenomenon.