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Efficacy and safety of a quick drying rubbing type povidone-iodine alcoholic disinfectant solution
Abstract:
The efficacy and safety of a quick drying rubbing type disinfectant (HAD Hand Wash) composed of a povidone-iodine (PVP-I) and ethanol were evaluated in the disinfection of transient skin flora on fingers of 30 medical staff of our department. Three millilitres of HAD solution was rubbed onto the hands for three minutes several times a day over a four week period. Bacteriological effects were evaluated twice, on the first day and after four weeks, by the palm stamp method. The rate of colonies sterilized (bacterial reduction rate) after the use of HAD Hand Wash was 86.9 +/- 21.2% (mean +/- SD) on the first measurement, and 91.5% +/- 12.8% at four weeks. Staphylococcus epidermidis was isolated most frequently and this was eradicated in 83.3% of subjects, the bacterial reduction rate 99.7%. Staphylococcus aureus was originally isolated in 14 subjects and was eradicated in 13; the bacterial colony reduction rate was 99.9% showing high antiseptic efficacy. Although the bacterial reduction rate for Bacillus sp. was a rather low, 75.8-100%, this result was not considered problematic from the clinical standpoint. There were no side effects like chapping in spite of an average 104 applications of HAD Hand Wash during the 4-week test period. From these results, HAD Hand Wash was considered highly effective and safe.
Insights
HAD Hand Wash, a povidone-iodine and ethanol disinfectant, effectively reduced transient skin flora on medical staff hands. This quick-drying hand rub demonstrated high safety with no side effects after frequent use.
Area of Science:
- Microbiology
- Infectious Disease Control
- Dermatology
Background:
- Transient skin flora on healthcare workers' hands can transmit infections.
- Effective hand hygiene is crucial for preventing healthcare-associated infections.
- Evaluating novel disinfectants is essential for improving infection control practices.
Purpose of the Study:
- To assess the efficacy and safety of HAD Hand Wash, a povidone-iodine and ethanol-based disinfectant.
- To evaluate the reduction of transient skin flora on the hands of medical staff.
- To determine the long-term effectiveness and safety profile of the disinfectant over a four-week period.
Main Methods:
- A four-week study involving 30 medical staff members.
- Application of 3 mL of HAD Hand Wash, rubbed for three minutes, multiple times daily.
- Bacteriological evaluation using the palm stamp method on day one and after four weeks.
Main Results:
- Significant bacterial reduction rates observed: 86.9% initially and 91.5% at four weeks.
- High eradication rates for common pathogens: Staphylococcus epidermidis (83.3% of subjects, 99.7% reduction) and Staphylococcus aureus (99.9% reduction).
- No adverse effects such as skin chapping reported despite an average of 104 applications per participant.
Conclusions:
- HAD Hand Wash is a highly effective and safe disinfectant for reducing transient skin flora.
- The disinfectant maintains efficacy over a four-week period with frequent application.
- Its safety profile makes it suitable for regular use in healthcare settings to enhance hand hygiene.