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[Collagenous colitis]

H Pallarés Manrique1, M J García Montes, S Díaz Cano

  • 1Servicio de Aparato Digestivo, Hospital Universitario, Virgen Macarena, Sevilla.

Revista Clinica Espanola
|November 1, 1993
PubMed
Summary
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Collagenous colitis can cause chronic diarrhea even with normal diagnostic tests. Rectosigmoid biopsies are recommended for diagnosing this condition when other analyses are inconclusive.

Area of Science:

  • Gastroenterology
  • Histopathology

Background:

  • Chronic diarrhea presents a diagnostic challenge, often requiring extensive investigation.
  • Collagenous colitis is an underdiagnosed cause of chronic watery diarrhea.

Observation:

  • Two female patients presented with chronic aqueous diarrhea.
  • Standard analyses, radiology, and endoscopy revealed no abnormalities.

Findings:

  • Sigmoid biopsies confirmed collagenous colitis in both patients.
  • One patient responded to omeprazole, the other to corticosteroids.

Implications:

  • Rectosigmoid biopsy is crucial for diagnosing collagenous colitis in chronic diarrhea cases.
  • Histopathological examination is essential despite normal endoscopic findings.