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Related Experiment Videos

Human postburn oedema measured with the impression method

O A Lindahl1, J Zdolsek, F Sjöberg

  • 1Department of Biomedical Engineering, Umeå University Hospital, Sweden.

Burns : Journal of the International Society for Burn Injuries
|December 1, 1993
PubMed
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Postburn tissue swelling, measured by skin compression, shows fluid accumulation peaking at 6 days. This study quanties generalized edema and increased tissue pressure in burn patients.

Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Physiology

Background:

  • Burn injuries cause significant tissue swelling (edema) due to fluid shifts.
  • Understanding the dynamics of postburn edema is crucial for patient management.
  • Non-invasive methods are needed to quantify these physiological changes.

Purpose of the Study:

  • To investigate the time course of tissue swelling in human skin after burn injury.
  • To quantify fluid translocation and interstitial pressure changes in postburn edema.
  • To model the compartmental fluid shifts contributing to generalized edema.

Main Methods:

  • A non-invasive impression technique was used to measure skin mechanical properties.
  • Force and tissue fluid translocation were recorded during skin compression.

Related Experiment Videos

  • Measurements were taken over 3 weeks in seven burn patients, with a mathematical model fitted to the data.

    • Main Results:

    • Tissue fluid translocation increased significantly, peaking at 6 days postburn, indicating progressive edema.
    • Impression force decreased significantly by 3 weeks, suggesting increased interstitial tissue pressure in the early postburn period.
    • Mathematical modeling revealed a fluid flux from the vasculature to the interstitial space within the first 6 days.

    Conclusions:

    • Postburn generalized edema continuously increases for the first 6 days.
    • Increased tissue pressure is evident in the early days following a burn.
    • The study quantifies the dynamic fluid shifts contributing to acute postburn edema.