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Dentinogenesis

A Linde1, M Goldberg

  • 1Department of Oral Biochemistry, Faculty of Odontology, University of Göteborg, Sweden.

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|January 1, 1993
PubMed
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It is time to move on.....

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Dentin formation (dentinogenesis) involves complex cellular and extracellular interactions, offering insights into biomineralization processes applicable to bone. This review details dentin structure, matrix, and mineral formation mechanisms.

Area of Science:

  • Biomineralization
  • Connective Tissue Biology
  • Odontoblast Differentiation

Background:

  • Dentinogenesis is a complex biological process involving cellular and extracellular factors.
  • Dentin, a calcified connective tissue, shares similarities in formation and composition with bone.
  • Studying dentinogenesis offers a valuable model for understanding biomineralization in other calcified tissues.

Purpose of the Study:

  • To review the intricate process of dentin formation (dentinogenesis).
  • To explore dentin structure, composition, and the role of the odontoblast.
  • To elucidate the mechanisms of biomineralization in dentin, with implications for bone biology.

Main Methods:

  • Review of existing literature on dentinogenesis and biomineralization.

Related Experiment Videos

  • Analysis of dentin structure, extracellular matrix components, and mineral ion transport.
  • Discussion of the odontoblast's role and proposed mineral formation mechanisms.

    • Main Results:

    • Dentinogenesis is a sophisticated interplay of cellular and extracellular components.
    • The odontoblast is the key cell responsible for dentin formation.
    • Mineralization involves specific organic matrix constituents and ion transport mechanisms.

    Conclusions:

    • Dentinogenesis serves as a practical model for studying biomineralization.
    • Understanding dentin formation enhances knowledge of bone biology and biomineralization processes.
    • Further research into dentin's organic matrix and mineralization mechanisms is warranted.