Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary sensory neuropathies

P K Thomas1

  • 1Department of Neurological Science, Royal Free Hospital School of Medicine, London, U.K.

Brain Pathology (Zurich, Switzerland)
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Appropriate Use of Single Inhaled Triple Therapy in Uncontrolled Asthma: A Multinational Modified Delphi Consensus.

Journal of asthma and allergy·2026
Same author

Correction: Expert Panel Consensus Recommendations for Allergic Rhinitis in Patients with Asthma in India.

Pulmonary therapy·2025
Same author

Expert Panel Consensus Recommendations for Allergic Rhinitis in Patients with Asthma in India.

Pulmonary therapy·2024
Same author

Pidotimod: In-depth review of current evidence.

Lung India : official organ of Indian Chest Society·2019
Same author

Overview of Charcot-Marie-Tooth Disease Type 1A.

Annals of the New York Academy of Sciences·2017
Same author

Guideline based management of bronchial asthma.

The Journal of the Association of Physicians of India·2014
Same journal

Non-Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies.

Brain pathology (Zurich, Switzerland)·2026
Same journal

A 3-year-old girl with a left optic nerve tumor.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Nearest-neighbors assisted unsupervised analysis for methylation array profiling for central nervous system tumors.

Brain pathology (Zurich, Switzerland)·2026
See all related articles

Hereditary sensory neuropathies lack genetic understanding compared to motor neuropathies. Classification relies on inheritance and clinical signs, with further research needed to define subtypes and genetic causes.

Area of Science:

  • Neurology
  • Genetics
  • Molecular Biology

Background:

  • Hereditary sensory neuropathies (HSNs) have lagged behind hereditary demyelinating motor and sensory neuropathies in molecular genetics advancements.
  • Current classification of HSNs is based on inheritance patterns and clinical presentation, with incomplete delineation of distinct syndromes.
  • Understanding the genetic basis of HSNs requires a more complete characterization of the clinical syndromes.

Purpose of the Study:

  • To highlight the current state of knowledge regarding hereditary sensory neuropathies.
  • To emphasize the need for further clinical delineation to facilitate genetic research.
  • To propose a framework for classifying HSNs based on clinical and genetic features.

Main Methods:

  • Review of existing literature on hereditary sensory neuropathies.

Related Experiment Videos

  • Analysis of current classification systems based on inheritance and clinical features.
  • Discussion of the relationship between clinical syndromes and potential genetic underpinnings.

    • Main Results:

    • Major advances in molecular genetics have not significantly impacted the understanding of HSNs.
    • Classification remains primarily clinical and based on inheritance patterns.
    • HSNs can be broadly categorized into those with sensory/autonomic features and those as part of multisystem degenerations.

    Conclusions:

    • Further clinical characterization of HSN syndromes is a prerequisite for identifying their genetic basis.
    • A more refined classification will aid in targeted genetic studies.
    • Future research should focus on integrating clinical, genetic, and molecular data to advance HSN understanding.