Related Experiment Video
Updated: Jul 25, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
The cell biology of bone
1Department of Medicine, University of Pennsylvania, Philadelphia.
Abstract:
Bone remodelling and repair are accomplished by the co-ordinated activity of cells of the osteoclast and osteoblast lineages. Small changes in the balance between formation and resorption will, when magnified by repeated cycles, lead to significant reduction in bone mass and strength, ultimately resulting in fracture. This review focuses on the cellular features of bone remodelling and the known regulators of bone cell function. These include systemic and local factors, both soluble and contained within the complex extracellular matrix of bone.
Related Concept Videos
Bone Remodeling
Osteoclasts in Bone Remodeling
Bone as Supporting Connective Tissue
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Cells and Tissue
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
The Bone Matrix
Bone Remodeling and Repair

